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| Tuesday, September 19th , 1950 |
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| Trenton Eagles: SP Warren Akers retired from professional baseball. |
| Trenton Eagles: CF Bob Kirby retired from professional baseball. |
| Trenton Eagles: 1B Jerry Byrd retired from professional baseball. |
| Hartford Colonials: RP Wingo Newhouse retired from professional baseball. |
| Wilmington Pipers: SP Paul Czerwinski retired from professional baseball. |
| Monday, August 21st , 1950 |
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| Wilmington Pipers: Placed SP Gene Smith on the 10-day injured list, retroactive to 08/19/1950. |
| Monday, July 10th , 1950 |
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| Albany Knickerbockers: Released RP Vic William. |
| Hartford Colonials: Released RF Irv Hopkins. |
| Hartford Colonials: Released CF Gus Nicolaides. |
| Monday, July 3rd , 1950 |
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| Albany Knickerbockers: Activated SP Roy Baker from the injured list. |
| Albany Knickerbockers: Released SS Hal Stone. |
| Albany Knickerbockers: Released CF Ed Filson. |
| Monday, June 5th , 1950 |
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| Albany Knickerbockers: Placed SP Roy Baker on the 10-day injured list, retroactive to 06/02/1950. |
| Hartford Colonials: Placed CF Gus Nicolaides on the 10-day injured list, retroactive to 06/02/1950. |
| Hartford Colonials: Placed SP Tom Gearhart on the active roster. |
| Monday, May 1st , 1950 |
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| Hartford Colonials: Placed SP Tom Gearhart on the 10-day injured list, retroactive to 04/28/1950. |
| Monday, April 17th , 1950 |
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| Albany Knickerbockers: Appointed Alex Modglin as Pitching Coach. |
| Albany Knickerbockers: Appointed Ernie Hill as Hitting Coach. |
| Albany Knickerbockers: Appointed Jack Hanible as Manager. |
